病理科
      广东省妇幼保健院病理科始建于上世纪八十年代,承担医院的临床诊断、教学及科研的任务。经过30年的努力,现在已经成为在广东省有一定影响力的病理科。每年的组织活检量约30,000余例,液基细胞学30,000余例,尸体解剖100余例,免疫组化8,000项次,分子病理2,000项次。病理科负责基层妇幼保健院的病理医师培训及实习生的教学工作,已经培养实习、进修医师100余名,参与培养研究生30余名。近几年来,病理科获得广东省科技厅及卫生厅科研基金10余项,获科研资助经费50多万元。发表论文100余篇,获得科学技术奖励三等奖。2012年获评为广东省临床重点专科。
     
      人员组成:病理科技术力量雄厚,共有医技术人员21名,其中医生11名,技术人员10名。特聘教授1名,高级职称4人,中级职称3人,博士5名,硕士3名。科室多次选派人员去北京、上海、天津等地区知名医院的病理科进修学习,诊断水平全省领先。
 
      仪器设备:病理科具有国内外的先进仪器与设备,德国Leica冷冻切片机2台、全自动组织脱水机3台,组织包埋机2台,组织切片机2台,全自动染色机2台,全自动封片机1台,罗氏免疫组化仪1台,罗氏原位杂交仪1台,奥林巴斯显微镜7台,荧光显微镜1台,Thinprep2000液基细胞制片仪1台等设备。
 
      科室开展工作:
⑴常规病理诊断:手术切除的组织(标本)必须进行病理检查,发报告时间为4个工作日。引进快速病理切片技术,特殊需要的病例发报告时间可缩短至1个工作日。
⑵液基细胞学:我院是最早开展液基细胞学进行宫颈癌筛查的医院,每年筛查人员30,000例左右,其他胸腹水也进行液基细胞学检查。
⑶术中快速冷冻切片:术中需要病理诊断的组织进行快速冷冻切片,确定肿瘤良恶性、浸润深度、切缘的情况等,每年完成3,000例术中冷冻切片,冷冻切片与最终病理诊断符合率99.9%。
⑷免疫组织化学染色:可以鉴别肿瘤良恶性、肿瘤类型、肿瘤免疫表型及癌基因扩张情况,为临床的诊断治疗提供分子依据。
⑸原位杂交:对细胞、组织中的病毒基因、癌基因等进行标记:如HPV病毒,乳腺HER2基因,宫颈癌TERC基因等,为临床靶向治疗提供依据。
⑹DNA倍体分析:通过观察细胞DNA倍体情况,判断细胞的良恶性,两倍体为良性,异倍体考虑恶性,在宫颈癌筛查、胸腹水细胞学检查,肿瘤穿刺细胞学等具有重要的意义。
 
 

微信名称:广东省妇幼保健院病理科 微信号:gdsfyblk

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Department of pathology,

Guangdong Women and Children Hospital

 

      Founded in 1980s, Pathology Department of Guangdong Women and Children Hospital, is responsible for clinical diagnosis, training and scientific research, and is priority specialty of Guangdong Province. The department has developed rapidly in the last few years. In 2012, biopsy samples were 30000, thinprep cytology tests were 30000, autopsy was 200, immunohistochemistry was 8000, and molecular pathology such as FISH was 2000. The Department of pathology also takes the task of training the pathology doctors and interns for primary women and children hospitals, and it has trained 100 interns and visiting students, as well as 30 graduate students. The Department of pathology have undertaken more than nine Guangdong Province Medical Scientific Research Foundations and one Guangdong Province Science and technology Planning project, and has been granted the third prize of science and technology awards. Nearly 100 academic papers have been published. In 2012, it has been awarded as a Key Clinical Department of Guangdong Province.
 
      Staff composition: The pathology department has abundant technical strength. Department of pathology is composed of 11 clinical doctors and 10 technicians, including one distinguished professor, 4 with senior professional titles, 3 with intermediate professional titles, 9 with doctoral degree and 3 with master degree. The department send personnel to studying in well-known hospitals at Beijing, Shanghai, Tianjin and other areas for many times. The diagnosis level of department is the province's lead.
           
       Instrument and equipment: We have many advanced instruments and equipments, such as one freezing microtome of the German Leical, two automatic dehydrators for tissues, two tissue embedding machines, two histotomes, two full automatic staining machines, one full automatic mounting machine, one Roche immunohistochemistry instrument, one Roche situ hybridization instrument, seven Olympus microscopes, one fluorescence microscopes, one Thinprep 2000 liquid-based cell production instrument and other equipments.
 
      Diagnosis and Laboratory technique
1.Clinical pathology: Tissue specimen from patients must be carried out pathologic examination. The result of diagnosis will be provided within 4 working days Since rapid pathological diagnosis technique was introduced, the result of diagnosis will be provided within 1 working day for special need.
 
2.Cytopathology: Cytopathology has been used for screening cervix cancer for many years in our hospital. The Department of Pathology receives more than 30000 cytological specimens for diagnosis per year. Cytopathology was also used for diagnosis of pleural fluid and ascitic fluid.
 
3.Intraoperative frozen section: Intraoperative frozen section was used for determination the benign and malignant tumor, invasive depth, margin, et al. The Department of Pathology receives more than 3000 frozen section specimens for diagnosis per year. The coincidence rate of pathological diagnosis between frozen section and paraffin embedding was 99.9%.
 
4.Immunohistochemistry Staining: We can differentiate benign or malignant tumors, tumor types, tumor immunophenotypes and oncogene amplification, so as to provide molecular basis for clinical diagnosis and treatment.
 
5.In situ Hybridization: We can use the markers in cells and tissues for virogenes, oncogenes and etc. Such as: HPV virus, HER-2 gene in breast, TERC gene of cervical cancer, and etc, so as to provide the basis for clinical targeted therapy.   
 
6.DNA ploidy analysis: We can make judgments in benign or malignant cells through the observation of the DNA ploidy situation in cells. Diploid is considered benign, and aneuploid refers to malignant. It has important significance in cervical cancer screening, pleural effusion and ascites cytological examination, tumor pricking cytology, and etc.